puzzlepuzzlepuzzles1noun1something that is difficult to understand or explain: Janet's reason for leaving her job is a puzzle to me.2a game that is difficult and makes you think a lotLook also at crossword puzzle and jigsaw puzzle.puzzlepuzzlepuzzlespuzzledpuzzling2verb (puzzles, puzzling, puzzled)to make you feel that you cannot understand or explain something: Tim's illness puzzled his doctors.