painpainpainspainedpainingnoun1(pluralpains) the feeling that you have in your body when you are hurt or ill: I've got a pain in my leg. He's in terrible pain.2(no plural) unhappiness: Her eyes were full of pain.be a pain or a pain in the neck (informal) a person, thing or situation that makes you angry or annoyed: She can be a real pain when she's in a bad mood.