puffpuffpuffs2nouna small amount of air, wind, smoke, etc. that is blown from somewhere: a puff of smokepuffpuffpuffspuffedpuffing1verb (puffs, puffing, puffed)1to smoke a cigarette, pipe, etc.: He sat puffing his cigar.2(used about air, smoke, wind, etc.) to blow or come out in clouds: Smoke was puffing out of the chimney.Stop puffing cigarette smoke in my face.3(informal) to breathe quickly or loudly, especially after you have been running: She was puffing as she ran up the hill.